Representação social da malária na perspectiva dos garimpeiros em Boa Vista ­ Roraima / Social representation of malaria from the prespective of miners in Boa Vista ­ Roraima / Representación social de la malaria en la perspectiva de los mineros de Boa Vista ­ Roraima

Objetivo: analisar o núcleo central da representação social acerca da malária na ótica dos garimpeiros e dos indivíduos que exercem atividades laborais em região de garimpo que buscam atendimento no Pronto Atendimento Cosme e Silva em Boa Vista/RR. Método:estudo descritivo exploratório de carácter qualitativo delineado por meio da Teoria das Representações Sociais, formulada por Serge Moscovici em 1961. Foram realizadas 72 entrevistas semiestruturadas com garimpeiros. A análise dos dados ocorreu com o auxílio do software OpenEvoc 0.92 desenvolvido pelo Prof. Dr. Hugo Cristo em 2012. Resultados: foi constatado que as percepções dos garimpeiros acerca da malária está diretamente relacionada com a sintomatologia da doença, principalmente pelos traumas vivenciados devidoa ausência de serviço de saúde disponível no local de trabalho. Enquanto que, as percepções dos garimpeiros sobre o garimpo estão vinculadas a condição econômica deste grupo. Conclusão:observa-se que a busca pelo bem-estar financeiro, faz o garimpeiro se submeter às relações extremamente precárias de trabalho, incluindo a exposição ao vetor da malária.

Objective: to analyze the central nucleus of the social representation about malaria from the perspective of miners and individuals who carry out work activities in a mining region who seek care at the Cosme e Silva Emergency Room in Boa Vista/RR. Method:descriptiveexploratory study of a qualitative nature outlined through the Theory of Social Representations, formulated by Serge Moscovici in 1961. 72 semi-structured interviews were carried out with miners. Data analysis took place with the aid of the OpenEvoc 0.92 software developed by Prof. Dr. Hugo Cristo in 2012. Results:it was found that the prospectors' perceptions about malaria are directly related to the symptoms of the disease, mainly due to the traumas experienced due to the lack of health services available in the workplace. Meanwhile, the prospectors' perceptions about mining are linked to the economic condition of this group. Conclusion:it is observed that the search for financial well-being makes the prospector submit to extremely precarious work relationships, including exposure to the malaria vector.

Objetivo: analizar el núcleo central de la representación social sobre la malaria en la perspectiva de mineros y personas que ejercen actividades laborales en una región minera que buscan atención en el Servicio de Emergencia Cosme e Silva de Boa Vista/RR. Método:estudio descriptivo exploratorio de carácter cualitativo esbozado a través de la Teoría de las Representaciones Sociales, formulada por Serge Moscovici en 1961. Se realizaron 72 entrevistas semiestructuradas con mineros. El análisis de datos se llevó a cabocon la ayuda del software OpenEvoc 0.92 desarrollado por el Prof. Dr. Hugo Cristo en 2012. Resultados:se encontró que las percepciones de los prospectores sobre la malaria están directamente relacionadas con los síntomas de la enfermedad, principalmente debido a los traumas experimentados por la falta de servicios de salud disponibles en el lugar de trabajo. Por su parte, las percepciones de los buscadores sobre la minería están ligadas a la condición económica de este grupo. Conclusión: se observa que labúsqueda de bienestar económico hace que el prospector se someta a relaciones de trabajo extremadamente precarias, incluida la exposición al vector de la malaria.

Malária: A crise silenciosa em Alto Alegre, Roraima e o fantasma do garimpo na Terra Indígena Yanomami / Malaria: The Silent Crisis in Alto Alegre, Roraima and the Specter of Mining in the Yanomami Indigenous Land / Malaria: La crisissilenciosa en Alto Alegre, Roraima y el fantasma de la minería en la Tierra Indígena Yanomami

Objetivo:analisar a evolução dos casos de malária em Roraima, principalmente no município de Alto Alegre, estratificado por aglomerações por área geográfica habitada -rural, urbana e área indígena no período de 2013 a 2022. Método:Estudo ecológico do tipo série temporal baseado em dados secundários dos casos confirmados de malária em Roraima, no período de 2013 a 2022. Resultados:nesse período foram confirmados 72.828 casos de malária em Roraima, dos quais 78,0% foram por Plasmodium vivax. Além disso, a maior parte dos casos se concentrou no município de Alto Alegre, correspondendo a 41,1%. Portanto, este foi o município que mais produziu malária procedente de garimpo, apesar de existirem outros que registraram aumento da doença nesse período. Conclusão:assim, osmunicípios de Alto Alegre, Amajari, Caracaraí, Iracema e Mucajaí, juntos respondem por 77.8% de toda malária produzida em Roraima. Estes municípios fazem parte da rota do garimpo ilegal na terra indígena Yanomami.

Objective: analyze the evolution of malaria cases in Roraima, especially in the municipality of Alto Alegre, stratified by geographical areas of habitation -rural, urban, and indigenous areas, from 2013 to 2022. Method: A time series ecological study based on secondary data of confirmed malaria cases in Roraima from 2013 to 2022. Results:During this period, 72,828 cases of malaria were confirmed in Roraima, of which 78.0% were due to Plasmodium vivax. Furthermore, the majority of cases were concentrated in the municipality of Alto Alegre, accounting for 41.1%. Therefore, this was the municipality that produced the most malariafrom mining activities, despite others experiencing an increase in the disease during this period. Conclusion: Thus, the municipalities of Alto Alegre, Amajari, Caracaraí, Iracema, and Mucajaí together accounted for 77.8% of all malaria cases produced in Roraima. These municipalities are part of the illegal mining route within the Yanomami indigenous land.

Objetivo: analizar la evolución de los casos de malaria en Roraima, principalmente en el municipio de Alto Alegre, marcado por aglomeraciones por área geográfica habitada -rural, urbana, en el área indígena en el período comprendido desde 2013 hasta 2022. Método: Estudio ecológico de tipo serie temporal basado en datos secundarios de los casos confirmados de malaria en Roraima, en el periodo de 2013 hasta 2022. Resultados: Durante este periodo fueron confirmados 72.828 casos de malaria en Roraima, de los cuales 78,0% correspondieron a Plasmodium Vivax. Además, la mayor parte de los casos estaban concentrados en el municipio de Alto Alegre, correspondiendo a 41,1%. Por lo tanto, este fue el condado que más produjo malaria proveniente de la minería, a pesar de existir otros que registraron aumentos de la enfermedad durante este periodo. Conclusión: Siendo así, los condados de Alto Alegre, Amajari, Caracaraí, Iracema y Mucajaí, juntos representan el 77.8% de toda la malaria existente en Roraima. Estos condados hacen parte de la ruta de minería ilegal en tierras indígenas Yanomam.

Medicina personalizada en urología: Perspectiva desde un sistema de salud con escasez / Personalized Medicine in Urology: Perspective from a Sparse Health System

La medicina personalizada (MP) trae la promesa del cuidado individual a través de la identificación de variaciones genéticas que permitan determinar la predisposición ante una enfermedad, ofreciendo una prevención oportuna y específica, o adaptando las estrategias terapéuticas de manera particular.[1] [2] Su esencia es la integración de la investigación biomédica y la información clínica,[3] [4] con la esperanza de reducir el gasto en salud y la garantía de acceso equitativo a los ciudadanos.[4] La rapidez y bajo costo en la secuenciación del genoma ha permitido su implementación en la práctica clínica.[1] En urología estos avances han facilitado una mejor comprensión de los subtipos histológicos de las neoplasias del tracto genitourinario, facilitando el uso de tratamientos específicos y un seguimiento más oportuno.[2] [5] [6] Sin embargo, su aplicación en la identificación de biomarcadores no ha sido completamente determinada

Personalized medicine (PM) brings the promise of individualized care through the identification of genetic variations that allow determining the predisposition to a disease, offering timely and specific prevention, or adapting therapeutic strategies in a particular way.[1] [2] Its essence is the integration of biomedical research and clinical information,[3] [4] with the hope of reducing health spending and guaranteeing equitable access to citizens.[4] The speed and low cost of genome sequencing has allowed its implementation in clinical practice.[1] In urology, these advances have facilitated a better understanding of the histological subtypes of histological subtypes of neoplasms in urology. The speed and low cost of genome sequencing has allowed its implementation in clinical practice.[1] In urology these advances have facilitated a better understanding of the histological subtypes of neoplasms of the genitourinary tract, facilitating the use of specific treatments and more timely follow-up.[2] [5] [6] However, its application in the identification of biomarkers has not been fully determined.

Third trimester HbA1c and the association with large-for-gestational-age neonates in women with gestational diabetes

ABSTRACT Objective: To evaluate the association between HbA1c levels measured in the third trimester and the risk for large for gestational age (LGA) in neonates of mothers affected by gestational diabetes mellitus (GDM). Secondarily, we aimed to identify an ideal cut-off for increased risk of LGA amongst pregnant women with GDM. Materials and methods: Observational retrospective review of singleton pregnant women with GDM evaluated in a diabetes and pregnancy clinic of a tertiary and academic hospital. From January/2011 to December/2017, 1,085 pregnant women underwent evaluation due to GDM, of which 665 had an HbA1c test in the third trimester. A logistic regression model was performed to evaluate predictors of LGA. A receiver-operating-characteristic (ROC) curve was used to evaluate the predictive ability of third trimester HbA1c for LGA identification. Results: A total of 1,085 singleton pregnant women were evaluated during the study period, with a mean age of 32.9 ± 5.3 years. In the multivariate analysis, OGTT at 0 minutes (OR: 1.040; CI 95% 1.006-1.076, p = 0.022) and third trimester HbA1c (OR: 4.680; CI 95% 1.210-18.107, p = 0.025) were associated with LGA newborns. Using a ROC curve to evaluate the predictive ability of third trimester HbA1c for LGA identification, the optimal HbA1c cut-off point was 5.4% where the sensitivity was 77.4% and the specificity was 71.7% (AUC 0.782; p < 0.001). Conclusions: Few studies in the Mediterranean population have evaluated the role of HbA1c in predicting neonatal complications in women with GDM. A third trimester HbA1c > 5.4% was found to have good sensitivity and specificity for identifying the risk of LGA.

Mesotelioma de túnica vaginal en paciente con hidrocele rápidamente progresivo / Mesothelioma of the Tunica Vaginalis in a Patient with Rapidly Progressive Hydrocele

El mesotelioma es una entidad poco común y agresiva que compromete el mesotelio, involucrando así los diferentes órganos cubiertos por membranas serosas. El mesotelioma de túnica vaginal es una neoplasia muy rara, con un cuadro clínico poco específico y de difícil diagnóstico con las técnicas imagenológicas actuales. Presentamos el caso de un paciente con hidrocele rápidamente progresivo que fue llevado a hidrocelectomía. Se realizó un diagnóstico histopatológico de mesotelioma epitelial maligno de túnica vaginal que requirió orquidectomía radical, hemiescrotomectomía y linfadenectomía retroperitoneal. A un año de seguimiento, el paciente no tiene evidencia de la enfermedad.

Mesothelioma is an uncommon and aggressive entity that compromises the mesothelium, thus involving the different organs covered by serous membranes. The mesothelioma of the tunica vaginalis is a very rare neoplasm, with a non-specific clinical picture and difficult diagnosis with current imaging techniques. We report the case of a patient with rapidly progressive hydrocele who was taken to hydrocelectomy. A histopathological diagnosis of epithelial mesothelioma of the tunica vaginalis was made, which required radical orchiectomy, hemiscrotectomy and retroperitoneal lymphadenectomy. At one year of follow-up, the patient has no evidence of the disease.

Odontogenic cysts: a descriptive clinicopathological study

Odontogenic cysts are lesions that deserve every attention, mainly because of all complications they can cause. To study their characteristics, the authors did a retrospective clinicopathological analysis of 124 oral biopsies that were diagnosed as odontogenic cysts, in Hospital Geral de Santo António - Porto. Clinical variables such as age, sex, location, clinical diagnosis and histological diagnosis were studied. Inflammatory radicular cysts were the most commons (48.4%) followed by dentigerous cysts (21.0%), residual cysts (17.7%)and keratocysts (12.1%). The most frequent clinical manifestation was swelling (62.9%). Age appears to be related to the type of cyst, expressing the etiopathologic characteristics of each one. It is concluded that a definitive diagnosis is based on a triad of radiology, clinics and histology, which presupposes a tight cooperation between the clinician and the histopathologist